SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF ACETYLENIC AMINO ALCOHOLS N-PHENYL CARBAMATE DERIVATIVES
Ключевые слова:carbamates, acetylene amino alcohols, bactericidal properties, microorganisms, microbiological activity.
The paper presents the results of synthesizing of acetylenic amino alcohols N-phenyl carbamate
derivatives and the microbiological evaluation of the latter has been studied. The following microorganisms were
considered as objects of microbiological research: Bacillus subtilis, Botrytis cinerea, Echerchia coli, Ervinia
caratovorum, Candida albicans, Fusarum solani и Helminthosporium. There were researched physicochemical and
bactericidal properties of acetylenic amino alcohols N-phenyl carbamate derivatives. The output of carbamates
depends on the content and structure of acetylenic amino alcohols and is 68-88%. The purity, identification and
structure of the compounds obtained been has determined by thin-layer and gas-liquid chromatography, elemental
analysis, IR (Infrared) and PMR (Proton Magnetic Resonance) spectroscopy. It established that these compounds
exhibit high antimicrobial activity against the causative agents of certain animal and plant diseases. The relatively
high microbiological activity of the phenylcarbamates studied is associated with the presence of various functional
groups in the composition of the molecules.