SYNTHESIS AND PHYSICOCHEMICAL PROPERTIES OF ACETYLENE AMINO ALCOHOLS
Ключевые слова:
acetylene amino alcohols, carbamic acids, carbamates, thiocarbamates, microbiological activity.Аннотация
The article is given an overview of publications devoted to the synthesis of acetylenic amino alcohols
and the possibility of obtaining on their basis of microbiologically active compounds by interaction with phenyl
isocyanate and phenyl isothiocyanate. Acetylene amino alcohols having not only biological activity, but also other
valuable properties, are also the basis for obtaining their derivatives. The yield of derivatives of acetylene amino
alcohols by Manich reaction was 66-73%. Implementation of the reaction at high temperature leads to the passing of
side processes, in particular, the decomposition of acetylene alcohols, resin formation and others.
Absorption spectra corresponding to functional groups and bonds of acetylene amino alcohols are observed on
IR spectra. Physical and chemical characteristics of acetylene amino alcohols were determined: boiling point, chromatographic
characteristics of Rf substance, elemental composition of carbon, hydrogen, nitrogen (mass.) and gross
formulas.
