ROLE OF MICRORNA AND POLYMORPHISMS OF FOXP3 AND ADRB2 GENES IN PATHOGENESIS OF PULMONARY DISEASES

Аннотация

The study of the key mechanisms of the development of bronchopulmonary diseases as asthma and
chronic obstructive pulmonary disease (COPD) and asthma and chronic obstructive pulmonary disease overlap
syndrome (ACOS) are the current directions of molecular medicine. Genetic predisposition as well as influence of
environmental factors play an important role in the development of asthma and COPD which are multifactorial
diseases. Epigenetic mechanisms also affect regulation of gene expression during asthma, COPD and ACOS. The
epigenetic regulation includes methylation of DNA, microRNA, histone modifications and they are all induced by
influence of environmental factors. Higher levels of methylation of FOXP3 and ADRB2 DNA are at a higher risk of
asthma development. However, there is not enough evidence on the level of methylation of the FOXP3 and ADRB2
genes and microRNA in patients with COPD and ACOS. It should be noted that the epigenetic labels established
during the study of cancer and autoimmune disorders have shown their value as biomarkers of diagnosis. In this case,
the study of genetic and epigenetic mechanisms of asthma, COPD and ACOS is a relevant objective of biomedicine
because it helps to explain the interaction between genes and environmental factors in order to develop diagnosis and
personalized treatment for the patients with bronchopulmonary diseases