THE PRECLINICAL EFFECT OF NATURAL DRUGS IN COMBINATION WITH CYTOSTATICS UPON THE GROWTH OF THE INITIAL AND DRUG-RESISTANT METASTASIS OF TUMORS
Ключевые слова:
Sarcoma 45, Pliss lymphosarcoma, Lewis pulmonary carcinoma, melanoma B-16, drug resistance, herbal preparations.Аннотация
The effect of various combinations of herbal preparations and anti-cancer compounds in rats with
drug-resistant models of metastasis of Pliss's lymphosarcoma was studied. Obtained a pronounced antimetastatic
effect alhidin combination with vincristine and alhidin with methotrexate in the experiments with the platform,
resistant to rubomycin (lack of development of metastases in the inguinal lymph nodes, IL 174%). The combination
of the effect of alidina to prospidine (ELE – extended life expectancy -308%) with an increase in immunological
(cellular) indicators from them. Metastases did not develop in rats with metastasis of Pliss's lymphosarcoma resistant
to lamattina from combinations of alhidin+cyclophosphamide, alhidin+sarcolysine and alhidin + prospidin +
cyclophosphamide; ELE – extended life expectancy was 207%. Alhidin on mice with Lewis lung carcinoma as
separately, and in combination with platidiam, cyclophosphamide and 5-fluorouracil caused a pronounced anti
allergic effect: metastases did not develop 98% of the rats, ELE – extended life expectancy – 248%.
