TY - JOUR AU - Zhonderbek Zhazyra Aybekkyzy, AU - Kolumbayeva Saule Zhanabayevna, AU - Lovinskaya Anna Vladimirovna, AU - Voronova Nina, PY - 2021/04/13 Y2 - 2024/03/29 TI - STUDY OF ANTIGENOTOXIC POTENTIAL OF THE ROSEHIP (ROSA MAJALIS HERRM.) OF THE FAMILY ROSACEAE JF - Научный журнал «Доклады НАН РК» JA - ДНР VL - IS - 2 SE - Статьи DO - UR - https://journals.nauka-nanrk.kz/reports-science/article/view/359 SP - 54-60 AB - <p>Increasing the body's resistance to various environmental pollutants' adverse effects is one of<br>medicine's essential tasks. In this regard, an active search for antimutagens to eliminate or weaken mutagens' effect<br>in the body is currently underway. One of the promising sources of antimutagenic compounds is the medicinal plant<br>Rosa majalis Herrm (rosehips). The genotoxic and antigenotoxic activity of rosehips was studied on cells of bone<br>marrow, spleen, liver, and kidneys of laboratory mice using an alkaline variant Comet assay. It was found that<br>rosehip infusions in various concentrations (infusion, diluted infusion and herbal tea) do not have a genotoxic effect<br>on the cells of the studied organs of laboratory animals. The medicinal rosehip's combined action with classical<br>mutagen MMS significantly reduced (p&lt;0.01) MMS-induced mutagenesis level. The various rosehip infusions used<br>did not show statistically significant differences among themselves. The results obtained indicate the antigenotoxic<br>activity of R. majalis infusions.</p> ER -