@article{Mantler S.N._Zhakanov M.M._Adekenov S.M._2020, title={BIOSYNTHESIS AND DYNAMICS OF ACCUMULATION OF SESQUITERPENE LACTONES IN ARTEMISIA GLABELLA KAR. ET KIR. }, url={https://journals.nauka-nanrk.kz/chemistry-technology/article/view/445}, abstractNote={<p>The study of biosynthetic processes in plant cells and methods for their regulation is an important<br>aspect in the development of biotechnological methods for the production of valuable medicinal compounds. The<br>identification and establishment of enzyme structures involved in the formation of secondary metabolites in plants by<br>using molecular genetic methods is one of the relevant ways in the study of their biosynthesis. For a successful<br>search, it is necessary to use plant organs with their quantitative accumulation.<br>In this work for the first time, a quantitative assessment of the content of sesquiterpene lactones arglabin and<br>argolide in CO2-extracts of Artemisia glabella Kar. et Kir. individual organs were performed at different stages of the<br>growing period (start of regrowth, end of regrowth, budding, flowering, fruiting); using electron scanning<br>microscopy, the leaves surface morphology was determined. It was found that the quantitative accumulation of<br>arglabin is observed during budding stage and its amounts are 1.90% in leaves and 1.56% in buds. On the surface of<br>leaves Artemisia glabella Kar. et Kir., there are capitate glandular trichomes of an oval shape, the sizes of which vary<br>between 70-80 microns in length and 33-38 microns in width.<br>Based on the obtained experimental data, we assume that the leaves and buds of intact plant Artemisia glabella<br>Kar. et Kir. during the budding stage will be the optimal samples to search for genes involved in the biosynthesis of<br>sesquiterpene lactones.</p>}, number={4}, journal={Известия НАН РК. Серия химии и технологии}, author={Mantler S.N. and Zhakanov M.M. and Adekenov S.M.}, year={2020}, month={сен.}, pages={22–29} }