TY - JOUR AU - Vladymyrova Inna, AU - Georgiyants Victoriya, AU - Savelieva Elena, PY - 2019/02/11 Y2 - 2024/03/28 TI - PHARMACOTHERAPEUTIC ACTION ANALYSYS OF MINERAL SUBSTANCES OF MEDICINAL PLANTS, WHICH ARE USED IN THYROID GLAND DISEASES JF - Научный журнал «Вестник НАН РК» JA - ВНР VL - IS - 1 SE - Статьи DO - UR - https://journals.nauka-nanrk.kz/bulletin-science/article/view/1598 SP - 6-13 AB - <p>Diseases of thyroid gland refer to the most widely spread ones, and are accompanied by the change<br>of hormonal background of the human organism in the whole and lead to disorders of vitally important processes in<br>other organs, triggering appearance of concomitant diseases. Among major causes of thyroid gland diseases are<br>psychological and emotional overloads; malnutrition and unbalanced nutrition that results in deficiency of mineral<br>substances and vitamins in the organism; radioactive conditions and unfavorable ecological situations; chronic<br>diseases.<br>Taking into account such a great role of macro- and microelements in the normal work of the thyroid gland, it is<br>necessary to provide their physiologically necessary content in the organism. The sources of mineral substances can<br>be medicinal plants and remedies made of them.<br>Therefore, the aim of the work was to determine content of macro- and microelement composition of medicinal<br>plants - Lycopus herb, Feijoa leaves, Cetraria islandica thalli, Bugleweed European herb, Genista herb, leaves of<br>Lemna minor, thalli of Fucus vesiculoses and thalli of Laminaria, which are used in treatment of thyroid gland<br>diseases and their water extracts and 10 %, 30 % and 50 % alcohol tinctures. Quantitative content determination of<br>macro- and microelements has been carried out by the atomic emission spectrography method. Quantitative<br>determination of general iodine content has been performed by the iodometry method (titrant – 0.01 М sodium<br>thiosulphate solution) after preliminary burning of the raw material in the alkaline solution by the methodology of<br>State Pharmacopoeia of Ukraine 2.0 volume 3, monograph «Buri vodorosli».<br>The presence of 15 macro and microelements has been determined in the result of the performed spectral<br>analysis of the studied types of medicinal plant raw materials and their extracts. Silicium, mangan, magnesium,<br>calcium, sodium and potassium are contained in comparatively big amounts. When determining qualitative and<br>quantitative content of mineral substances our attention was focused on the elements which had great significance at<br>diseases of thyroid gland, the deficiency or misbalance, which can damage the thyroid gland or other organs<br>functioning, the use of which can eliminate negative symptomatic manifestations in diseases of thyroid gland (Fe,<br>Mn, Mg, Ca, Cu, Zn, Se, I). The representatives of brown algae – Laminaria (0,11 %) and Fucus (0,05 %) and also<br>the representative of fresh water reservoirs – duckweed (0,028 %) are characterized by the highest iodine content.<br>The samples of Laminaria, Fucus, Feijoa and Lemna (duckweed) were characterized by the highest iodine content.<br>The most maximum iodine content had water extracts, when ethyl alcohol concentration was increased, the iodine<br>content didn’t change significantly. High selenium content has been determined in the thalli of Laminaria (0,81<br>mg/kg), Lemna (duckweed) (0,72 mg/kg) and fresh Feijoa fruit (0,31 mg/kg). The highest selenium content (mkg/l)<br>had water Fucus extract (40) and 50 % Lemna (duckweed) tincture (14). There is an interesting fact, that iodin:<br>selenium ratio in these samples was 1:4(5), that can stipulate similar mechanisms of the effect for thyroid gland.<br>Among the tested substances high selenium and iodine content had simultaneously Laminaria samples – 5 % tincture<br>(3,8) and 10 % tincture (6,6). Though the iodine: selenium ratio had another character and made 18(19):1.</p> ER -